Adaptation is mandatory for lung IMPT

Intensity-modulated proton therapy (IMPT) can lower the dose to organs-at-risk (OAR) compared with photon therapy. Researchers at Aarhus University Hospital advise that the majority of patients receiving IMPT for loco-regional lung cancer will benefit from this approach, but will require daily imaging and therapy adaptation. This is due to the risk of large anatomical changes during the treatment course, including atelectasis (lung collapse), pleural effusion and differential motion of malignant lymph nodes and the primary tumour.