Adding antiangiogenesis increases effectiveness of radiation against NF2-associated tumours

Treatment with antiangiogenesis drugs may improve the effectiveness of radiation treatment of nervous system tumours that interfere with the hearing of patients with the genetic disorder neurofibromatosis 2 (NF2). A team of Massachusetts General Hospital (MGH) investigators reports in PNAS Early Edition that use of an antiangiogenesis drug reduced the radiation dose required to shrink tumors in animal models of the NF2-associated tumours called vestibular schwannomas. They also discovered several mechanisms behind this effect and determined the time window during which radiation therapy produces the best results in the tested model.

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