Curbing inflammation after radiotherapy slows pancreatic tumour growth in mice

University of Pennsylvania scientists have zeroed in on a resistance mechanism that plays a role in making pancreatic cancer so difficult to treat: inflammation that occurs in response to treatment. The Penn team discovered comparatively high levels of inflammatory compounds in mice with pancreatic tumors. These included CCL2, the signaling molecule that activates CCR2, a receptor on some white blood cells that promotes their recruitment by tumors. The mice’s CCL2 levels increased further after they received radiotherapy.
Fierce Biotech