Ludwig researchers unravel novel mechanism by which tumours grow resistant to radiotherapy

A Ludwig Cancer Research study has uncovered a key mechanism by which tumours develop resistance to radiotherapy and shown how such resistance might be overcome with drugs that are currently under development. The discovery addresses a longstanding challenge: as many as 40% of large tumours develop resistance to radiotherapy, significantly complicating treatment. Overcoming such resistance could go a long way toward treating tumours, especially those that cause significant discomfort to patients and resist other modes of therapy or cannot be surgically removed.