No long-term benefit from radiotherapy escalation in low-risk prostate cancer

A review of 12 randomized controlled trials from 1990 or later of escalating external-beam radiation therapy (EBRT) in 6,884 men with localized prostate cancer found improvement in freedom from biochemical failure (FFBF) but not in overall survival, cancer metastasis, or cancer-specific death at 5 and 10 years. These results add to the evidence questioning aggressive local treatment strategies in men with low-risk disease.

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