Nodal stage migration in anal cancer may misclassify true disease stage

The rate of lymph node positivity in patients with squamous cell carcinoma of the anus may be overestimated, potentially leading to the over-treatment of patients with chemo-radiotherapy, according to a meta-regression analysis that included over 60 studies and more than 10,000 patients. The results were published in Lancet Oncology.
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