Radio-surgery or whole-brain radiotherapy in patients with multiple brain metastases?

Although targeted therapies have produced dramatic advances in our ability to control some types of advanced lung cancer, growth of the disease in the brain remains a major problem. Radiotherapy is often used to treat deposits in the brain, but the best technique to deliver radiotherapy can be controversial. Whole-brain radiotherapy, as its name suggest, treats the entire brain but can be associated with notable cognitive side effects. Another strategy, radio-surgery, directs highly-focused radiation only to the sites of metastasis, largely sparing the normal brain.
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