Revised understanding of graft-versus-host disease origins offers new direction for potential therapy

An international research team led by the University of Michigan Life Sciences Institute is changing the understanding of the key cellular and molecular events that trigger graft-versus-host disease, an often fatal complication of bone marrow transplants. The transplant’s power comes from the ability of the donor cells to find and attack lingering cancer cells in the patient following chemotherapy or radiation treatment—but graft-versus-host disease develops when the new immune cells attack the transplant recipient, too.
Medical Press