Treatment-resistant cancers have Achilles’ heel. Common vulnerability is druggable pathway leading to iron-induced cell death

Through mutations or changes in gene expression patterns, some cancer cells become resistant to common treatments such as radiotherapy, chemotherapy, targeted drug therapy, and immunotherapy. A new study reports that these resistant cancers do have a vulnerability: They depend on an enzyme to protect them from iron-produced free radicals. The work opens a potential new route to fight cancer in people who currently lack good treatment options because conventional ones don’t work, say the researchers, led by Stuart L. Schreiber of Broad Institute and Harvard University.