Why combined therapies increase survival in prostate cancer

Researchers at Karolinska Institutet, SciLifeLab and Centre for Clinical Research, Västerås have been able to explain why a combination of castration therapy and radiation therapy increases survival rates for patients with prostate cancer, compared to if they only receive radiation therapy. The findings, which are presented in the journal Science Translational Medicine, show that castration therapy impairs the DNA-repair machinery of the cancer cells, making them more sensitive to radiation.

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