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January 17, 2020

Prostate deaths hit record high of 12,000 after soaring by more than a quarter in less than 20 years - while the breast cancer toll dropped by 1,600 in the same period

Prostate cancer deaths have passed 12,000 a year for the first time. The toll has risen by more than a quarter in less than 20 years, official figures show. By contrast, the number of annual deaths from breast cancer dropped by nearly 1,600 between 1999 and 2017, from 12,947 to 11,371. Annual prostate deaths have risen by nearly 2,600 in the same period, from 9,460 to 12,031 – a 27 per cent increase. Our ageing population is the main reason, with older men more likely to develop the disease. However, the number of patients diagnosed with breast cancer has also risen – yet the number of deaths has fallen.

January 17, 2020

Prostate cancer: only one in four men with metastatic disease gets recommended chemotherapy

A national audit shows that only one in four men with advanced prostate cancer receives life prolonging chemotherapy despite its recommendation by the National Institute for Health and Care Excellence (NICE). The National Prostate Cancer Audit’s annual report 2019 for England and Wales, published by the Royal College of Surgeons, reported for the first time on the use of primary docetaxel in metastatic disease. It found that only 27% of men with widespread disease received docetaxel, ranging from 0% to 39% by NHS providers in England.

Report: National Prostate Cancer Audit

January 17, 2020

Deborah James: You, Me and the Big C podcast host 'in cancer-free place'

One of the hosts of BBC Radio 5 Live's podcast You, Me and the Big C has revealed she is now "in a cancer-free place" after three years of treatment. "It's a bit bonkers... but right now I have no evidence of cancer in my body," Deborah James said on Instagram. James, who was diagnosed with incurable bowel cancer in 2016, told her 91,000 followers she was "beyond grateful". "I never ever thought we would be here," she told BBC Breakfast on Wednesday. "It's only just sinking in.

January 17, 2020

Galliford Try wins £26m Cheshire cancer centre job

Galliford Try has won a £26m deal to build a cancer centre in Macclesfield. Designed by AFL Architects, the two-storey scheme was approved by Cheshire East council in September and will be The Christie’s first project outside Greater Manchester. Set to be completed by summer next year, work will start in earnest on site in the next few weeks once an existing mental health unit on the site has been demolished. Located at the Macclesfield District General Hospital, the centre will combine radiotherapy, chemotherapy and palliative care services along with a clinical trials facility.

January 16, 2020

Radiotherapy can be used in hard-to-treat bladder cancer

More targeted forms of radiotherapy can effectively treat bladder cancer which has spread to the lymph nodes of the pelvis, according to a new clinical trial. This form of cancer – known as node positive bladder cancer – has a particularly poor prognosis and hasn’t usually been treated with radiotherapy. Patients are traditionally offered palliative treatment to manage their pain and other symptoms instead. Scientists at The Institute of Cancer Research, London, in conjunction with researchers and clinicians at The Royal Marsden NHS Foundation Trust, conducted a phase II clinical trial assessing the use of radiotherapy in patients with bladder cancer which had spread to the pelvic lymph nodes.

Original Article: Clinical Oncology

January 16, 2020

Top News From SABCS 2019: Slideshow

The 2019 San Antonio Breast Cancer Symposium took place between 11th and 14th December. This slideshow summarises some of the important research updates presented at this conference.

January 16, 2020

Combined proton–photon treatments – A new approach to proton therapy without a gantry

Although the number of proton therapy centres is growing worldwide, proton therapy is still a limited resource. The primary reasons are gantry size and cost. Therefore, we investigate the potential of a new design for proton therapy, which may facilitate proton treatments in conventional bunkers and allow the widespread use of protons. Combined proton–photon treatments may play a role in developing a new solution for proton therapy without a gantry. Optimal combinations improve on IMRT plans and reduce the risk of side effects while making protons available to more patients.

January 16, 2020

Accuray CyberKnife® System Provides Excellent Disease Control for Men with Recurrent Prostate Cancer, a Medical Condition with Few Viable Treatment Options

Accuray Incorporated announced data from a prospective study which showed that at five years, stereotactic body radiation therapy (SBRT) administered with the CyberKnife® System provided excellent disease control with low rates of toxicity in men with locally recurrent prostate cancer after previous treatment with radiation therapy. Importantly, 69% of men required no androgen deprivation therapy (ADT) treatment within the first five years following CyberKnife prostate SBRT. ADT, also known as "hormone therapy," is the most common treatment given for recurrent prostate cancer. However, its use is associated with unfortunate side effects including loss of libido, hot flashes, bone fractures, loss of muscle mass and physical strength, and weight gain.

Original Article: International Journal of Radiation Oncology Biology Physics

Original Article: International Journal of Radiation Oncology Biology Physics

January 15, 2020

Report calls for better imaging for patients with suspected bowel obstructions

The RCR has welcomed calls for better diagnosis and management of patients with potentially deadly bowel obstructions, while cautioning that the UK’s shortage of scanners and radiologists is hampering improvements. A report from the National Confidential Enquiry into Patient Outcome and Death (NCEPOD) compiled evidence from UK-wide case reviews and clinician surveys to make a series of recommendations for improving the care of adults with acute bowel obstruction. It stresses the need for dedicated management pathways and better access to vital CT scans and surgical treatments. The report estimates pathway improvements could impact nearly 800,000 patients who present to Accident and Emergency (A&E) departments each year with abdominal symptoms that could be life-threatening bowel obstructions.

Report: National Confidential Enquiry into Patient Outcome and Death (NCEPOD)

January 15, 2020

Better Intellectual Outcomes After Proton Beam for Brain Cancer

A new study shows that children with medulloblastoma who were treated with radiotherapy had better intellectual outcomes when the radiation was delivered as proton beam therapy compared to traditional photon radiotherapy. Proton beam radiotherapy remains controversial, mainly because it is more expensive than traditional radiotherapy and there is little evidence to show that the extra cost is worth it. The main advantage claimed for proton therapy is a reduction in adverse effects. This has been particularly emphasized for children with brain cancer. "Our findings show a clear cognitive advantage with proton radiotherapy, even in the context of craniospinal irradiation," said study author Lisa S. Kahalley, PhD, associate professor and director of research, Baylor College of Medicine and Texas Childrens Hospital, Houston.

Original Article: Journal of Clinical Oncology


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